20/02/2019. Nocne dyżury powodują u lekarzy uszkodzenie DNA

by Krystyna Knypl February. 20, 2019 293 views

Badania laboratoryjne na szczurach i myszach wykazują, że zaburzenia snu powodują u nich uszkodzenie DNA. Zwierzęta laboratoryjna zamknięte dla dobra nauki w klatkach, pozbawione możliwości snu doznawały uszkodzenia DNA. Takie zmiany wykazało wiele doniesień naukowych. Po raz pierwszy wykazano, że zamknięcie lekarzy w klatce 24 godzinnych dyżurów także powoduje uszkodzenie DNA, zmniejszają się antyoksydacyjne możliwości osocza, a stąd już prosta droga do zawałów serca, udarów mózgu, zaburzenia funkcji poznawczych w starszych latach....

Więcej w doniesieniu V. Cheung i wsp.

The effect of sleep deprivation and disruption on DNA damage and health of doctors

https://onlinelibrary.wiley.com/doi/full/10.1111/anae.14533

W czasach mojej lekarskiej młodości krążyła taka urban legend o pewnym chirurgu: gdy przyjmował nad ranem kolejnego pacjenta wymagającego wykonania zabiegu operacyjnego w krótkim czasie, lecz nie natychmiastowym, przychodził do pacjenta i mówił tak: powinien być pan zoperowany w ciągu kilku godzin, ja operuję już 20 godzin i mogę pana zacząć operować za chwilę. Musi pan wiedzieć, że o 8:00 rano przyjdą moi koledzy, którzy będą wyspani oraz wypoczęci, oni też mogą pana zoperować. Przez kogo chce pan być operowany?
Wszyscy pacjenci woleli być operowani przez wyspanych chirurgów...

# 1 Skok na...

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  • 1. Andersen ML, Ribeiro DA, Bergamaschi CT, et al. Distinct effects of acute and chronic sleep loss on DNA damage in rats. Progress in Neuro‐Psychopharmacology and Biological Psychiatry 2009; 33: 562–7. Crossref CAS PubMed Web of Science®Google Scholar

  • 2. Bellesi M, Bushey D, Chini M, Tononi G, Cirelli C. Contribution of sleep to the repair of neuronal DNA double‐strand breaks: evidence from flies and mice. Scientific Reports 2016; 6: 36804. Crossref CAS PubMed Web of Science®Google Scholar

  • 3. Everson CA, Henchen CJ, Szabo A, Hogg N. Cell injury and repair resulting from sleep loss and sleep recovery in laboratory rats. Sleep 2014; 37: 1929–40. Crossref PubMed Web of Science®Google Scholar

  • 4.Tenorio NM, Ribeiro DA, Alvarenga TA, et al. The influence of sleep deprivation and obesity on DNA damage in female Zucker rats. Clinics (Sao Paulo) 2013; 68: 385–9. Crossref PubMed Web of Science®Google Scholar

  • 5. Arnardottir ES, Nikonova EV, Shockley KR, et al. Blood‐gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep 2014; 37: 1589–600. Crossref PubMed Web of Science®Google Scholar

  • 6. da Costa Souza A, Ribeiro S. Sleep deprivation and gene expression. Current Topics in Behavioral Neurosciences 2015; 25: 65–90. Crossref PubMedGoogle Scholar

  • 7. Carroll JE, Cole SW, Seeman TE, et al. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence‐associated secretory phenotype (SASP) in aged adult humans. Brain, Behavior, Immunity 2016; 51: 223–9. Crossref CAS PubMed Web of Science®Google Scholar

  • 8. Prather AA, Leung CW. Association of insufficient sleep with respiratory infection among adults in the united states. Journal of the American Medical Association Internal Medicine 2016; 176: 850–2. Web of Science®Google Scholar

  • 10. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Analytical Biochemistry 1996; 239: 70–6. Crossref CAS PubMed Web of Science®Google Scholar

  • 11. Benjamin DJ, Berger JO, Johannesson M, et al. Redefine statistical significance. Nature Human Behaviour 2017; 1: 6. Google Scholar

  • 12. Lin X, Chen W, Wei F, Ying M, Wei W, Xie X. Night‐shift work increases morbidity of breast cancer and all‐cause mortality: a meta‐analysis of 16 prospective cohort studies. Sleep Medicine 2015; 16: 1381–7. Crossref PubMed Web of Science®Google Scholar

  • 13. Manzella N, Bracci M, Strafella E, et al. Circadian modulation of 8‐Oxoguanine DNA damage repair. Scientific Reports 2015; 5: 13752. Crossref PubMed Web of Science®Google Scholar

  • 14. Bernstein C, Bernstein H. Epigenetic reduction of DNA repair in progression to gastrointestinal cancer. World Journal of Gastrointestinal Oncology 2015; 7: 30–46. Crossref PubMed Web of Science®Google Scholar

  • 15. Hung RJ, Hall J, Brennan P, Boffetta P. Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. American Journal of Epidemiology 2005; 162: 925–42. Crossref PubMed Web of Science®Google Scholar

  • 16. Vgontzas AN, Zoumakis M, Bixler EO, et al. Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin‐6 and cortisol levels: physiologic and therapeutic implications. Journal of Clinical Endocrinology and Metabolism 2003; 88: 2087–95. Crossref CAS PubMed Web of Science®Google Scholar

  • 17. Wang XS, Armstrong ME, Cairns BJ, Key TJ, Travis RC. Shift work and chronic disease: the epidemiological evidence. Occupational Medicine 2011; 61: 78–89. Crossref PubMed Web of Science®Google Scholar

  • 18Kubo T, Ozasa K, Mikami K, et al. Prospective cohort study of the risk of prostate cancer among rotating‐shift workers: findings from the Japan collaborative cohort study. American Journal of Epidemiology 2006; 164: 549–55. Crossref PubMed Web of Science®Google Scholar

  • 19. Schernhammer ES, Laden F, Speizer FE, et al. Night‐shift work and risk of colorectal cancer in the nurses’ health study. Journal of the National Cancer Institute 2003; 95: 825–8. Crossref PubMed Web of Science®Google Scholar

  • 20. Tynes T, Hannevik M, Andersen A, Vistnes AI, Haldorsen T. Incidence of breast cancer in Norwegian female radio and telegraph operators. Cancer Causes and Control 1996; 7: 197–204. Crossref CAS PubMed Web of Science®Google Scholar

  • 21. Collins KP, Geller DA, Antoni M, et al. Sleep duration is associated with survival in advanced cancer patients. Sleep Medicine 2017; 32: 208–12. Crossref PubMed Web of Science®Google Scholar

  • 22. Vyas MV, Garg AX, Iansavichus AV, et al. Shift work and vascular events: systematic review and meta‐analysis. British Medical Journal 2012; 345: e4800. Crossref PubMed Web of Science®Google Scholar

  • 23. Ju SY, Choi WS. Sleep duration and metabolic syndrome in adult populations: a meta‐analysis of observational studies. Nutrition and Diabetes 2013; 3: e65. Crossref PubMed Web of Science®Google Scholar

  • 24. Gan Y, Yang C, Tong X, et al. Shift work and diabetes mellitus: a meta‐analysis of observational studies. Occupational and Environmental Medicine 2015; 72: 72–8. Crossref PubMed Web of Science®Google Scholar

  • 25. Tranah GJ, Blackwell T, Stone KL, et al. Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Annals of Neurology 2011; 70: 722–32. Wiley Online Library PubMed Web of Science®Google Scholar

  • 26. Rothman SM, Herdener N, Frankola KA, Mughal MR, Mattson MP. Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Abeta and pTau in a mouse model of Alzheimer's disease. Brain Research 2013; 1529: 200–8. Crossref CAS PubMed Web of Science®Google Scholar

  • 27. Bryant PA, Trinder J, Curtis N. Sick and tired: does sleep have a vital role in the immune system? Nature Reviews Immulogy 2004; 4: 457–67. Crossref CAS PubMed Web of Science®Google Scholar

  • 28. Hirotsu C, Tufik S, Andersen ML. Interactions between sleep, stress, and metabolism: from physiological to pathological conditions. Sleep Science 2015; 8: 143–52. Crossref PubMed Web of Science®Google Scholar

  • 30. Molina Aragones JM, Ayora Ayora A, Barbara Ribalta A, et al. Occupational exposure to volatile anaesthetics: a systematic review. Occupational Medicine 2016; 66: 202–7. Crossref CAS PubMed Web of Science®Google Scholar

  • 31. Stern MP. Diabetes and cardiovascular disease. The “common soil” hypothesis. Diabetes 1995; 44: 369–74. Crossref CAS PubMed Web of Science®Google Scholar

@mimax2 /Krystyna Knypl, lekarz

Gazeta dla Lekarzy (GdL), redaktor naczelna & wydawca

specjalista chorób wewnętrznych i hipertensjologii

specjalista European Society of Hypertension

https://sites.google.com/site/myjournalismkrystynaknypl/

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